Human Albumin 20% Injection

Human Albumin 20% Injection
Human Albumin is administered intravenously to restore and maintain oncotic pressure in patients experiencing conditions such as hypoalbuminemia or significant fluid loss. This preparation is designed to ensure optimal patient safety and efficacy, with stringent screening of donors and comprehensive processing to eliminate potential viral contaminants. The high purity and stabilization of the product further enhance its therapeutic profile, making it a reliable option in critical care settings.

As the major protein in human plasma, albumin plays two core roles: maintaining plasma colloid osmotic pressure and transporting endogenous substances (fatty acids, hormones, bilirubin) and exogenous agents (drugs). Its 20% hypertonic formulation enables rapid intravascular volume expansion—typically 3.5 times the infused volume within 15 minutes—by shifting fluid from the interstitial space to the circulation, effectively relieving edema and restoring hemodynamic stability.

Clinical indications include hypovolemic shock from hemorrhage, trauma, burns, or sepsis (when crystalloids are ineffective); hypoalbuminemia (serum albumin <25g/L) caused by cirrhosis, nephrotic syndrome, protein-losing enteropathy, or malnutrition; management of ascites and severe tissue edema; adjunctive therapy for neonatal hyperbilirubinemia, cardiopulmonary bypass, hemodialysis, and acute respiratory distress syndrome (ARDS); and prevention of circulatory dysfunction after large-volume paracentesis. It is not for nutritional supplementation in patients with normal serum albumin levels.

Administration is exclusively intravenous—undiluted or diluted with 0.9% sodium chloride/5% glucose; subcutaneous/intramuscular injection is prohibited. The initial infusion rate must not exceed 1 mL/min for the first 15 minutes to monitor for hypersensitivity. If tolerated, adjust to 1–2 mL/min for adults; reduce speed in elderly patients or those with heart failure. Dosage is individualized based on hemodynamic parameters (blood pressure, CVP, urine output, Hct), not just serum albumin levels: 12.5–25g (50–100mL) for hypovolemia (repeat in 30 minutes if needed); 5–10g daily for chronic hypoalbuminemia until edema resolves.

Contraindications: hypersensitivity to albumin/excipients, severe heart failure/pulmonary edema with normal/increased blood volume, and severe anemia. Use cautiously in patients with hypertension, renal impairment, coagulation disorders, pregnant/lactating women, and the elderly; avoid glucose diluents in diabetics.

Adverse reactions are mostly mild and transient: infusion site pain, fever, chills, flushing. Rare severe reactions (anaphylaxis, angioedema, respiratory distress) require immediate infusion cessation and resuscitation with epinephrine, antihistamines, or glucocorticoids. Inspect for clarity before use; do not freeze; use immediately once opened. It is a prescription blood product, requiring administration in medical settings with resuscitation facilities and continuous hemodynamic monitoring.