Dihydroartemisinin 40 mg +piperaquine 320mg Tabltes

dihydroartemisinin+piperaquine
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Product Description

Therapeutic action

  • Antimalarial

Indications

  • Treatment of uncomplicated falciparum malaria
  • Treatment of uncomplicated malaria due to other Plasmodium species, when chloroquine cannot be used
  • Completion treatment following parenteral therapy for severe malaria

Forms and strengths

  • Co-formulated tablets of dihydroartemisinin (DHA)/piperaquine (PPQ), in blister pack, for a complete treatment for one individual
  • There are 5 different blister packs:
    • 20 mg DHA/160 mg PPQ tablets   blister pack of 3 tablets*2
    • 40 mg DHA/320 mg PPQ tablets   blister pack of 3 tablets*2
    • 40 mg DHA/320 mg PPQ tablets   blister pack of 6 tablets*2
    • 40 mg DHA/320 mg PPQ tablets   blister pack of 9 tablets*2
    • 40 mg DHA/320 mg PPQ tablets   blister pack of 12 tablets*2

Dosage and duration

  • Child 5 to < 25 kg: 2.5 to 10 mg/kg daily of DHA + 20 to 32 mg/kg daily of PPQ
  • Child 25 kg and over and adult: 2 to 10 mg/kg daily of DHA + 16 to 27 mg/kg daily of PPQ

 

Weight

20 mg/160 mg tablet

40 mg/320 mg tablet

5 to < 8 kg

1 tab

8 to < 11 kg

1½ tab

11 to < 17 kg

1 tab

17 to < 25 kg

1½ tab

25 to < 36 kg

2 tab

36 to < 60 kg

3 tab

60 to < 80 kg

4 tab

≥ 80 kg

5 tab

  • Tablets are to be taken once daily for 3 days.

Contra-indications, adverse effects, precautions

  • Do not administer in the event of cardiac disorders (bradycardia, heart rhythm disorders, congestive heart failure).
  • Do not combine with drugs that prolong the QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.
  • Administer with caution to patients > 60 years or with renal or hepatic impairment.
  • May cause: cardiac disorders (QT prolongation, tachycardia); rarely, gastrointestinal disturbances, pruritus, hepatic disorders, joint and muscle pain.
  • Monitor combination with: antiretrovirals (increased blood levels of these drugs), enzymes inducers such as rifampicin, carbamazepine, phenytoin, phenobarbital (reduced blood levels of DHA/PPQ).
  • If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose.
  • Pregnancy: no contra-indication
  • Breast-feeding: no contra-indication

Remarks

  • Take 3 hours before or after meals, with a glass of water.
  • The tablets may be crushed and mixed with water.

Storage

          Below 25 °C